U.S. eyes planned Russian nuclear exercises amid NATO war games
U.S. Eyes Planned Russian Nuclear Exercises Amid NATO War Games
“We do know that, based on past precedent, the exercise likely will happen soon but no notifications at this time,” U.S. Defense Department spokesman Brigadier General Pat Ryder told reporters Thursday at the Pentagon. While both the NATO and Russian drills are long-planned and held each year, the exercises have not previously taken place against the backdrop of a large-scale European land war, where the risk of miscalculation is at its highest point since the Cold War.
The U.S. and NATO do not have forces inside Ukraine, where tens of thousands of Russian troops are in the midst of an illegal occupation, but they do have personnel and equipment throughout the European continent. Warplanes from the U.S. and Russia often fly in airspace relatively close to one another.
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Frequency, breed predispositions and other demographic risk factors for diagnosis of hypothyroidism in dogs under primary veterinary care in the UK - Canine Medicine and GeneticsBackground Hypothyroidism is a commonly diagnosed endocrinopathy in dogs. This study aimed to investigate the frequency and risk factors for diagnosis of hypothyroidism in UK primary-care practice. Dogs diagnosed with hypothyroidism were identified by searching electronic patient records of primary-care practices participating in VetCompass. A cohort study design estimated one-year (2016) period prevalence and incidence risk for hypothyroidism. Multivariable binary logistic regression models were used to evaluate associations between demographic risk factors and hypothyroidism. Results From 905,553 dogs, 2,105 dogs were recorded with diagnosed hypothyroidism in 2016; 359 incident and 1,746 pre-existing, giving an annual prevalence of 0.23% (95% CI 0.22–0.24) and annual incidence risk of 0.04% (95% CI 0.04–0.04). Multivariable logistic regression identified 24 predisposed and nine protected breeds. Standard Doberman pinscher (odds ratio [OR] = 17.02, 95% CI 12.8–22.64), Tibetan terrier (11.25, 95% CI 8.27–15.32) and boxer (10.44, 95% CI 8.66–12.58) breeds showed high predisposition. Pug (OR 0.29, 95% CI 0.09–0.89), Yorkshire terrier (OR 0.38, 95% CI 0.24–0.59), Shih-tzu (OR 0.38, 95% CI 0.23–0.64) and Jack Russell terrier (OR 0.40, 95% CI 0.29–0.54) were the most protected breeds. Overall, being a purebred dog, being insured, having bodyweight above the breed-sex mean, increasing age, being neutered and rising adult bodyweight also showed increased odds being a dog living with a diagnosis of hypothyroidism. Conclusions Several strong breed predispositions for diagnosis of hypothyroidism were identified that can assist with disorder prioritisation in ongoing efforts to improve breed health. Other risk factors were also identified that can assist veterinary surgeons during clinical work-up of suspected cases. Identification of novel evidence for protected breeds provides useful information for research into genetic mechanisms.
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What is the pensions triple lock and why is the government staying committed to the policy?For days, it appeared as though the annual rise guarantee for pensions was in doubt. Here we explain the long-standing manifesto pledge from the Conservative Party and its bumpy journey to remain as a policy.
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Association of Early Weight Change With Cognitive Decline in Patients With Parkinson DiseaseBackground and objective: To examine whether early weight change is associated with subsequent deterioration in cognitive function, including overall performance and specific domains, in Parkinson’s disease (PD). Methods: This observational study used data from the Parkinson’s Progression Markers Initiative cohort. The patients underwent annual non-motor assessments covering neuropsychiatric, sleep-related, and autonomic symptoms for up to 8 years of follow-up. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and detailed neuropsychological testing. Linear mixed-effects models were applied to investigate the association of early weight change with longitudinal evolution of cognitive and other non-motor symptoms. Results: A total of 358 early PD patients were classified into weight loss (decrease of |3% body weight during the first year; n=98), weight maintenance (within ±3%; n=201), and weight gain (increase of |3%; n=59) groups. The weight loss group showed a significantly faster decline in MoCA scores than the weight maintenance group (β=−0.19, 95% confidence interval [CI] −0.28 to −0.10). With respect to specific cognitive domains, the weight loss group showed a steeper decline in sematic fluency test scores (β=−0.37, 95% CI −0.66 to −0.08) and MoCA phonemic fluency scores (β=−0.18, 95% CI −0.31 to −0.05) and, to a lesser extent, Letter-Number Sequencing scores (β=−0.07, 95% CI −0.14 to 0.01) compared to the weight maintenance group. Conversely, the weight gain group showed a slower decline in the Symbol-Digit Modalities Test scores (β=0.34, 95% CI 0.05 to 0.63), although no association was found with longitudinal changes in MoCA scores. We did not find any significant effects of weight change on the progression of other non-motor symptoms. Discussion: Early weight loss was associated with a faster progression of decline in global cognitive function and executive function in PD patients, whereas early weight gain was associated with
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U.S. Eyes Planned Russian Nuclear Exercises Amid NATO DrillsAnnual planned 'Grom' and 'Steadfast Noon' nuclear war games take place amid grinding Ukraine conflict
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