Weight change in early Parkinson'sdisease may be tied to changes in thinkingskills
To examine whether early weight change is associated with subsequent deterioration in cognitive function, including overall performance and specific domains, in Parkinson’s disease .This observational study used data from the Parkinson’s Progression Markers Initiative cohort. The patients underwent annual non-motor assessments covering neuropsychiatric, sleep-related, and autonomic symptoms for up to 8 years of follow-up.
The weight loss group showed a significantly faster decline in MoCA scores than the weight maintenance group . With respect to specific cognitive domains, the weight loss group showed a steeper decline in sematic fluency test scores and MoCA phonemic fluency scores and, to a lesser extent, Letter-Number Sequencing scores compared to the weight maintenance group.
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