Pancreatic cancers are among the most aggressive, deadly tumor types, and for years, researchers have struggled to develop effective drugs against the tumors. Now, Salk Institute researchers have identified a new set of molecules that fuel the growth of tumors in pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer.
by activating a"super-enhancer" that turns on other genes. It also showed the effectiveness of a new drug that put the brakes on pancreatic cancer growth by blocking the effects of that super-enhancer.
In the new work, Evans' team analyzed 16 different human pancreatic cancer cell lines and identified hundreds of different super-enhancers. They pinpointed one, associated with the gene hnRNPF, that was far more active in pancreatic cancer cells than healthy cells. Then, through a series of experiments, the group showed how hnRNPF sets off a cascade of events leading to an increase in the amounts of overall proteins cells were producing.
They also found that an experimental drug targeting Prmt1, one of the proteins impacted by hnRNPF activation, could stop the growth of isolated pancreatic tumors in the lab and the growth of pancreatic tumors in mice.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Aging alters pancreatic circadian rhythm: StudyA new research paper titled 'Reorganization of pancreas circadian transcriptome with aging' has been published in Aging.
Læs mere »
- but not completely ignore - Super Mario Bros. Wonder's talking flowersSuper Mario Bros. Wonder includes chatty flowers which share jokes and useful hints as you pass by - though Nintendo ha…
Læs mere »
China’s Oil Giant CNOOC Shuts Down Oil Fields Amid Super TyphoonChina’s state-owned offshore giant China National Offshore Oil Corporation (CNOOC) has evacuated more than 10,000 workers from offshore production platforms, floating production and storage vessels in anticipation of Typhoon Saola
Læs mere »
Super League 2023: The state of play with the League Leaders' Shield, play-offs and relegationThere are just three rounds to go in the 2023 Betfred Super League regular season, with everything still to play for at both ends of the table.
Læs mere »
Brenko Lee's agent confirms Leeds Rhinos interest amid two-way battle for centreThe Queensland representative and NRL champion will head to Super League next year.
Læs mere »
Matt Frawley's first words after securing Super League return with Leeds RhinosFrawley has secured a deal with the former Super League champions, becoming their third signing for 2024.
Læs mere »