Researchers have discovered toll-like receptor 7 (TLR7), a nucleic acid sensor within the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, to be aberrantly expressed in many types of cancers. However, its expression pattern across cancers and association with COVID-19 (or its causing virus SARS-CoV-2) has not been systematically studied.
Coronavirus disease 2019 is a disease mainly characterized by damage to the respiratory system caused bycoronavirus 2 . Recent studies suggest that cancer was a risk factor for coronavirus disease 2019 .
In this study, the authors of this article employed a computational framework to comprehensively study the roles of TLR7 in COVID-19 and pan-cancers at genetic,, protein, epigenetic, and single-cell levels. As a result, they found TLR7 expression to be higher in the lungs of mice infected with SARS-CoV-2 than in those of the control group.
This study reveals the roles of TLR7, a nucleic acid sensor for COVID-19 in pan-cancer. These findings could be significant in efforts to prevent SARS-CoV-2 infection and alleviate cytokine storms in infected cancer patients.Zhijian Huang et al, Revealing the roles of TLR7, a nucleic acid sensor for COVID-19 in pan-cancer,
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