Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden medrxivpreprint lunduniversity goteborgsuni SARSCoV2 infection reinfection Omicron
By Dr. Chinta SidharthanNov 17 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers from Sweden conducted a cohort study to evaluate the protection granted by previous severe acute respiratory syndrome coronavirus 2 Omicron subvariant infections against reinfections among individuals vaccinated between June and August 2022.
About the study In the present study, the researchers included individuals between the ages of 18 and 64, residing in Scania county in southern Sweden, who had received their first vaccination dose on or before 24 April 2021. Since healthcare workers were prioritized for the early vaccination program, the authors expected the study cohort to comprise mainly healthcare workers. The longitudinal study followed up with the participants until 9 August 2022 for positive SARS-CoV-2 tests.
Additionally, a 1:10 sex and age-matched control group with no positive SARS-CoV-2 tests during the same weeks as the infected cases was also included in the analysis. The protection against Omicron BA.5 infection was estimated using conditional logistic regression according to the time of the most recent SARS-CoV-2 infection, adjusted for the vaccine doses.
The study analyzed 1,114 COVID-19 reinfection cases, matched with 11,140 controls. The test and control groups were similar in demographic, socioeconomic factors, and comorbidities. Surprisingly, booster vaccinations were seen to have no significant effect on protection against reinfections, with a larger number of individuals with booster vaccinations present in the test group than in the control group.
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