What is the association between diabetes and SARS-CoV-2 infections? NaturePortfolio SARSCoV2 COVID19 Diabetes
By Pooja Toshniwal PahariaNov 15 2022Reviewed by Aimee Molineux In a recent review published in Nature Metabolism, researchers explored whether severe acute respiratory syndrome coronavirus 2 can expedite or trigger the development of diabetes mellitus .
Epidemiological and clinical evidence of diabetes and COVID-19 Multiple studies have reported an elevated risk of incident DM of type 1 and following SARS-CoV-2 infections. However, for T1D, epidemiological studies have reported controversial findings. Thus, dysglycaemia might represent a probable aspect of PASC . However, the diabetogenic effects of COVID-19 may not be direct results since hyperglycemia has been reported post-non-COVID ARDS , probably due to generalized inflammation. Nevertheless, the development of incident T2D and insulin resistance in the PASC phase indicates that COVID-19 could potentiate β cell exhaustion in high-risk individuals.
Studies have documented β cell infection among deceased COVID-19 individuals, resulting in lowered expression of insulin production- and release-associated genes. Specifically, COVID-19 has been associated with degranulation, impairments in the glucose-stimulated secretion of insulin, trans- or de-differentiation, and cell death.
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