Omicron BA.2 causes more symptoms and a greater disruption to daily life

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Omicron BA.2 causes more symptoms and a greater disruption to daily life
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Omicron BA.2 causes more symptoms and a greater disruption to daily life Omicron BA2 BA1 Coronavirus Disease COVID NatureComms imperialcollege UniofOxford

Study: Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England. ​​​​​​​Image Credit: NIAID

The REal-time Assessment of Community Transmission−1 study monitored the spread and clinical manifestation of SARS-CoV-2 monthly in the population in England between 1 May 2020 and 31 March 2022. Loss of sense of smell and taste and cold-like symptoms were less and more predictive of swab positivity for Omicron than for other variants, respectively. Specifically, Omicron infections were not so strongly associated with anosmia as previous variants. Likely, alterations in the viral gene sequences that regulate host responses in individuals infected with Omicron reduced the downregulation of expression of olfactory receptors, which caused anosmia following COVID-19.

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