Early life experiences can have long-lasting impact on genes uclnews NatureAging
early in life lived shorter lives, even after their diets were improved in adulthood. Here, they uncover the mechanism likely explaining the finding.
In their previous study, the researchers found that a high-sugar diet inhibited a transcription factor called dFOXO, which is involved inand is known from multiple studies to affect longevity, so they now sought to enact the opposite effect by directly increasing the activity of dFOXO. Transcription factors are proteins that regulate transcription, or copying, of information from DNA into messenger RNA, which is the first and key step in gene expression. For this study, the researchers activated dFOXO by increasing its levels in female fruit flies during the first three weeks of the fly's adulthood.
They found that these early-life experiences caused changes to chromatin—a mixture of DNA and proteins that can be seen as the 'packaging' of DNA—that persisted and resulted in genes being expressed differently late in life. This counteracted some changes that would be expected as part of the normal aging process, eventually improving health in late life and impacting the fruit flies' lifespan more than a month later.Dr.
early in life, for example, could impact our metabolism later in life by tweaking how our genes are expressed, even after substantial dietary changes over the years—but fortunately, it may well be possible to reverse this."to affect gene activity, we may be able to develop ways to counteract these changes later in life to preserve health and enable people to stay healthy for longer.
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