Biomarker in urine could be the first to reveal early-stage Alzheimer'sdisease frontiersin
Could a simple urine test reveal if someone has early-stage Alzheimer's disease and could this pave the way for large-scale screening programs? A new study incertainly suggests so. The researchers tested a large group of patients with Alzheimer's disease of different levels of severity and healthy controls with normal cognition to identify differences in urinary biomarkers.
"Alzheimer's disease is a continuous and concealed chronic disease, meaning that it can develop and last for many years before obvious cognitive impairment emerges," said the authors."The early stages of the disease occur before the irreversible dementia stage, and this is the golden window for intervention and treatment. Therefore, large-scale screening for early-stage Alzheimer's disease is necessary for the elderly.
A total of 574 people participated in the study, and participants were either healthy volunteers with normal cognition, or had differing degrees of disease progression, ranging from subjective cognitive decline to fully-fledged disease.
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