Effects of early postnatal exposure to antibiotics on incidence of early-onset sepsis CHUVLausanne Sepsis EarlyOnsetSepsis Antibiotics Exposure
By Neha MathurNov 30 2022Reviewed by Aimee Molineux In a recent study published in Jama Network Open, researchers investigated the effects of early postnatal exposure to antibiotics among infants in the participating networks of high-income countries. They also quantified the incidence of early-onset sepsis and mortality in all infants with a gestational age greater than or equal to 34 weeks, born between January 1, 2014, and December 31, 2018.
Neonatal antibiotic exposure disturbs the developing microbiome, resulting in several later diseases, including asthma, diabetes, allergy, and inflammatory bowel disease. Furthermore, these treatments adversely impact the duration of hospital stay and breastfeeding rates and increase health care costs. Overall, AMS is crucial in early life.
Regarding mortality, the team defined neonatal death as death before discharge or within 28 days among hospitalized cases. EOS-associated mortality was death within 28 days after positive blood or CSF culture. They calculated the proportion of newborns treated with antibiotics by dividing the number of newborns receiving a minimum of one dose of antibiotics in the first postnatal week by live births. The duration of antibiotic therapy was calendar days with at least one antibiotic dose.
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