A new editorial paper was published in Oncotarget, titled 'Inhibition of glutamine metabolism: acting on tumoral cells or on tumor microenvironment?'
' survival. So far, these treatments have not been able to induce a great overall benefit for patients due to the ability of tumor cells to alter their metabolism.after alterations in Gln metabolism in vivo, suggesting the possibility to combine glutamine dysregulation strategies with some other therapies increasing reactive oxidative species to promote cancer cell death.
In his new editorial, researcher Raul Peña from Institut Hospital del Mar d'Investigacions Mèdiques discusses a novel mechanism by which Gln, usually concentrated at the tumor periphery, acts as a chemoattractant for cancer-associated fibroblasts , enhancing extracellular matrix degradation and facilitating epithelial cancer cell migration and metastasis in vivo.
"Recently, we described a new action of Gln on cancer-associated fibroblasts in breast cancer. [...] In our study, we determined that mesenchymal-like epithelial breast tumor cells and CAFs present a higher dependence on Gln than tumor epithelial breast cancer cells," says Peña.Raul Peña, Inhibition of glutamine metabolism: acting on tumoral cells or on tumor microenvironment?,
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