A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases—and for those who would like to eat meat, but don't want to kill animals.
in the laboratory. In this case, they are mouse cells, but the researchers are also interested in human and cow cells.tissue cultured in the lab could be used in surgery, while human muscle stem cells could help people with muscle diseases; meanwhile, lab-grown cow muscle tissue could revolutionize the meat industry by enabling the production of meat with no need to slaughter animals.
"This approach enabled us to produce large quantities of muscle cells," explains Xhem Qabrati, a doctoral student in the Bar-Nur group and one of two lead co-authors on this study."Although muscle cells could also be cultured directly from muscle biopsies, the cells tend to lose their functionality after isolation, rendering it challenging to produce large quantities of cells."
Since this leaves the cells' genome unchanged, it avoids the negative consequences associated with such changes. The mRNA still enables the connective tissue cells to produce the MyoD protein, such that—together with the other components of the cocktail optimized by the ETH researchers—they can turn into muscle stem cells and fibers.. They are the first to reprogram connective tissue cells into muscle stem cells without genetic engineering.
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