Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism - Molecular Psychiatry

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Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism - Molecular Psychiatry
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Genemutation leading to autism found to overstimulate brain cells RutgersU MolPsychiatry

We thank the members of the Pang Lab for their insightful comments on the manuscript. We also thank Xueying Wang from Central South University for collecting the psychiatric risk summary gene list.This study was supported by grants from the Robert Wood Johnson Foundation to the Child Health Institute of New Jersey , the Governor’s Council for Medical Research and Treatment of Autism , and the NIMH , and by a predoctoral fellowship from the NIMH .

Child Health Institute of New Jersey and Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA Le Wang, Vincent R. Mirabella, Xiao Su, Matteo Bernabucci, Ishnoor Singh, Davide Comoletti & Zhiping P. Pang Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, 410008, Changsha, ChinaDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USADepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, 13210, USADepartment of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, 08854,...

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, ChinaHunan Key Laboratory of Animal Models for Human Diseases, Central South University, 410008, Changsha, Hunan, ChinaHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA

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Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism - Molecular PsychiatryAnalyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism - Molecular PsychiatryMolecular Psychiatry - Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
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