Scientists at the Garvan Institute of Medical Research have identified molecular profiles of the surrounding matrix of a common type of lung cancer that might indicate which patients are likely to develop aggressive tumors.
, a 3D meshwork of around 300 core molecules. This matrix is present in all tissues in the body, where it normally provides structural and functional support to hold cells together.
The team, led by Associate Professor Thomas Cox, comprehensively studied the molecular and protein composition of the matrix aroundThey identified two tumor matrix profiles—one in which patient prognosis was good, and the other where patients did poorly. These matrix profiles appear to be established early in the initiation of the tumor and persist as the tumor grows, controlling how the tumor will respond to chemotherapy treatment.
The tumor matrix in patients who fared worse had more collagen proteins and more fibrosis—stiffening of the tumor structure—suggesting that the tumor matrix remodels to protect itself against treatment.appear similar in the clinic, they are quite different in their matrix composition. These differences have the potential to be leveraged by existing therapies developed to treat other diseases.
"These two tumors look very similar under the microscope, and are typically treated the same way, but are very different on a," says Associate Professor Cox, head of the Matrix and Metastasis lab at Garvan."This sheds light on why some patients progress well and others don't, and how we might be able to stratify patients to provide more personalized treatment."
The next step is to engage with clinical partners to move toward a clinical trial for repurposing therapies that may prevent this matrix remodeling in lung cancer patients, and improve response to therapy.Extracellular Matrix Profiles Determine Risk and 1 Prognosis of the Squamous Cell Carcinoma Subtype of Non-Small Cell Lung Carcinoma,
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