What is the real-world efficacy of oral antivirals against the SARS-CoV-2 Omicron variant? univ_paris_cite Antiviral SARSCoV2 COVID19 Omicron
By Dr. Chinta SidharthanOct 12 2022Reviewed by Aimee Molineux In a recent article published in The Lancet, the authors commented on a recent observational study by Wong et al. , which explored the real-world effectiveness of oral antivirals against the severe acute respiratory syndrome coronavirus 2 Omicron variant.
The researchers found that molnupiravir users were older than the COVID-19 patients on nirmatrelvir plus ritonavir treatment. Nirmatrelvir plus ritonavir therapy is known to have many drug-drug interactions with prescription medications such as amiodarone, enzalutamide, rifampicin, carbamazepine, phenobarbital, St John’s Wort , phenytoin, and many more. Molnupiravir also had an earlier release date than nirmatrelvir plus ritonavir.
Commenting on the study by Wong et al., the authors stated that despite the inherent limitations of the observational study, it highlighted the relevant real-world findings of the effectiveness of the two oral antiviral therapies in preventing all-cause mortality within a community-dwelling population like Hong Kong. They mentioned that the study had a potential self-reporting bias since mildly symptomatic patients might not seek medical aid.
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