Geneticsequencing could be key to containing future COVID-19 variant outbreaks universityofga PNASNexus
, highlighting that with our parameterization, a 1-week reduction in the delay between exposure and the dissemination of sequencing results has an identical impact onto a five-fold increase in sequencing probability. In contexts where testing is constrained or costly, improvements in sequencing protocols can be decisive.Impact of infection sequencing ratio and sequence processing delays on variant identification. Sample realization of the variant emergence model.
With a doubling time of 7 days, the variant is identified before any infections are exported. For a variant with a 3-day doubling time, four infections are exported before the variant is identified. As the ratio of sequencing delay to doubling time increases, it is necessary to sequence a greater proportion of infections to have the same probability of identifying the variant before exportation,.
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