A new dementia risk score, which draws on 11 mostly modifiable risk factors, identifies people at risk—from mid-life onwards—of developing the disease within the next 14 years, suggests a large long-term study published in the open access journal BMJ Mental Health.
The UK Biobank Dementia Risk Score, or UKBDRS for short, outperformed three other widely used risk scores originally developed in Australia , Finland , and the UK , the findings show.
To try and get round these issues, the researchers drew on two large groups of 50 to 73-year olds participating in two long term studies—one group for developing the new risk score and one for validating it . The APOE gene, which is involved in the production of a protein that helps carry cholesterol and other types of fat in the bloodstream, is a known risk factor for dementia. Its carriage was known for 157,090 participants in the UK Biobank study and 2315 of those in the Whitehall II study and added to the risk score .
UKBDRS-APOE produced the highest predictive score, closely followed by the UKBDRS, and then age alone, followed by DRS, CAIDE, and finally ANU-ADRI. Referring to the illustrative example provided, she explains: *"While older age and APOE confer the greatest risk, modifiable factors, such as diabetes, depression, and high blood pressure also have a key role. For example, the estimated risk for a person with all of these will be approximately three times higher than that of a person of the same age who doesn't have any."
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
New risk score strongly predicts dementia chances within 14 yearsA new dementia risk score, which draws on 11 mostly modifiable risk factors, identifies people at risk—from midlife onward—of developing the disease within the next 14 years, suggests a large long term study published in the open access journal BMJ Mental Health.
Læs mere »
11 things that increase your risk of dementia the most, according to scientistsResearchers have identified the top risk factors for dementia, an illness that affects more than 944,000 people in the UK.
Læs mere »
Dementia risk factors list drawn up by scientists - including lifestyle choicesThe list was whittled down from 28 known factors linked to dementia risk, and was then used to develop a tool academics say can 'strongly predict' whether someone will develop the condition in the next 14 years.
Læs mere »
Scientists say 11 risk factors predict if person will get dementiaPeople can modify their lifestyles giving themselves a much better chance of avoiding the condition
Læs mere »
The 11 factors that increase dementia risk revealed – and one is your genderTargeting risk factors could avert 40% of cases.
Læs mere »
Dementia study reveals 11 signs that show you're at risk in next 14 yearsTargeting risk factors could avert 40% of cases.
Læs mere »