A new dementia risk score, which draws on 11 mostly modifiable risk factors, identifies people at risk—from midlife onward—of developing the disease within the next 14 years, suggests a large long term study published in the open access journal BMJ Mental Health.
A new dementia risk score, which draws on 11 mostly modifiable risk factors, identifies people at risk—from midlife onward—of developing the disease within the next 14 years, suggests a large long term study published in the open access journalThe UK Biobank Dementia Risk Score, or UKBDRS for short, outperformed three other widely used risk scores originally developed in Australia , Finland , and the U.K. , the findings show.
To try and get round these issues, the researchers drew on two large groups of 50- to 73-year-olds participating in two long term studies—one group for developing the new risk score and one for validating it . Within 14 years, 3,813 and 93 participants developed dementia in the UK Biobank and Whitehall II groups, respectively.
The researchers suggest that the accuracy of their risk score could be further improved by adding cognitive tests, a brain scan, and a blood test for indicators of neurodegeneration. But as these are expensive and/or time intensive they may not always be available. Referring to the illustrative example provided, she explains,"While older age and APOE confer the greatest risk, modifiable factors, such as diabetes, depression, and high blood pressure also have a key role. For example, the estimated risk for a person with all of these will be approximately three times higher than that of a person of the same age who doesn't have any."
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