The effects of theabrownin (TB) from dark tea treatment on insulin resistance (IR).
By Tarun Sai LomteSep 8 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nutrients, researchers assessed the effects of theabrownin from dark tea treatment on insulin resistance .
Maintaining metabolic homeostasis in the liver depends on the regulatory functions of glucagon and insulin. High-fat- and high-glucose-induced IR is associated with increased reactive oxygen species levels, leading to oxidative stress. About the study In the present study, researchers assessed how TB affects IR. TB was extracted following fermentation for seven days or 14 days . The ultraviolet-visible absorption spectra of the colloids were measured. Samples were also analyzed using Fourier-transform infrared spectroscopy.
Findings All samples showed absorption peaks at 205 nm and 275 nm. Peaks of TB1 were relatively lower than those of TB2. The degree of polyphenol polymerization was lower in TB1 samples, which may explain its reduced absorption . FTIR spectroscopy revealed that samples were rich in carboxylic and hydroxyl groups.
TB treatment increased superoxide dismutase, adenosine triphosphate , and glutathione levels and reduced mitochondrial ROS synthesis. TB2 was more potent in decreasing oxidative stress than TB1.
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