The shape and size of a grain of rice, the new device can conduct dozens of experiments at once to study the effects of new treatments on some of the hardest-to-treat brain cancers.
Researchers from Brigham and Women's Hospital, a founding member of the Mass General Brigham health care system, have designed a device that can help test treatments inThe device, which is designed to be used during standard of care surgery, provides unprecedented insight into the effects of drugs on glioma tumors and caused no adverse effects on patients in a phase 1 clinical trial.
One challenge in developing targeted therapies for glioma is that it can be difficult to test many different combinations of drugs in, because it's only possible to treat patients with one approach at a time. This has been a significant barrier for hard-to-treat cancers like gliomas, for which combination therapies are a promising avenue.
In the time the device is implanted—about two to three hours—it administers tiny doses of up to 20 drugs into extremely small areas of the patient's brain tumor. The device is removed during the surgery and the surrounding tissue is returned to the lab for analysis.
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