The surprising cancer symptom on your nails and nine other signs you must not ignore
having a change in a cough you have had for a long time - it may sound different or be painful when you coughcoughing up phlegm with blood in itchest infections that keep coming back or a chest infection that doesn't get betterThey said that it's still important to contact your GP if your have a new or worsening cough as they can speak to you over the phone or by a video call and arrange for tests if you need them.
Most people who have this type of cancer will suffer severe shoulder pain, or pain that travels down the arm.People with this might experience a drooping or weakness of one eyelid or a small pupil in the eye.
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Frontiers | Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinomaBackground: Early detection and intervention research is expected to improve the outcomes for patients with invasive urinary bladder cancer, specifically muscle invasive urothelial carcinoma (InvUC). With limited patients in suitable high-risk study cohorts, identifying relevant animal models for this research is critical. Experimental animal modes, while essential in InvUC research, often fail to adequately represent human cancer, and fail to predict drug responses. The purpose of this study was to define a naturally-occurring canine model for early intervention research by studying dogs with high breed-associated risk for InvUC, e.g. Scottish Terriers (STs). Methods: STs (n=120) ≥ 6 years old with no outward evidence of urinary disease were screened at 6-month intervals for 3 years. Screening included physical exam with digital rectal exam, ultrasonography, and urinalysis with sediment exam. Cystoscopic biopsy was performed in dogs with positive screening tests. The pathological, clinical, and molecular characteristics of the “early” cancer detected by screening were determined. Transcriptomic signatures were compared between the early tumors and published findings in human InvUC, and to more advanced “later” canine tumors from STs who had the typical clinical presentation of hematuria and urinary dysfunction. An early intervention trial of an oral cyclooxygenase inhibitor, deracoxib, was conducted in dogs with cancer detected through screening. Results: Biopsy-confirmed bladder cancer was detected in 32 (27%) of 120 STs including InvUC (n=29, three starting as dysplasia), grade 1 noninvasive cancer (n=2), and carcinoma in situ (n=1). Transcriptomic signatures including druggable targets such as EGFR and the PI3K-AKT-mTOR pathway, were very similar between canine and human InvUC, especially within luminal and basal molecular subtypes. Marked transcriptomic differences were noted between the early and later canine tumors, particularly within luminal subtype tumors.
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Shropshire cancer charity gets £95k boost to ‘go mobile’ and boost cancer awarenessA brand-new exhibition van will be hitting Shropshire’s roads and towns as part of the fight to beat cancer – thanks to a generous £95,000 donation from a county business. Shropshire Charity LingenDavies
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Advanced cancer survival rates 'could double within a decade', say scientistsThe Institute of Cancer Research (ICR) says it has launched a 'really exciting' five-year research strategy which hopes to 'unravel and disrupt cancer's ecosystems'.
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Tumor matrix profiling gives clues to progression of some lung cancersScientists at the Garvan Institute of Medical Research have identified molecular profiles of the surrounding matrix of a common type of lung cancer that might indicate which patients are likely to develop aggressive tumors.
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Physicians urged to consider fungal infections as possible cause for lung inflammationInfectious diseases expert George Thompson has been studying and treating fungal diseases for over two decades. He monitors their spread, symptoms and relative risks. Lately, he has been more concerned about a rising threat: the spread of disease-causing fungi outside of their traditional hot spots.
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York: CCTV released as detectives probe serious assaultThe victim suffered a collapsed lung and fractured eye socket in the assault, police say.
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