Researchers discuss the potential of probiotic- and prebiotic-based interventions for managing cardiovascular diseases.
By Neha MathurAug 28 2023Reviewed by Benedette Cuffari, M.Sc. In a recent article published in Nutrients, researchers discuss the potential of probiotic- and prebiotic-based interventions for managing cardiovascular diseases .
Considerable research has indicated that the gut microbiota during early life influences the risk of CVD later in life. In fact, several in vivo studies have confirmed the efficacy of prebiotics, probiotics, and postbiotics in reducing the risk of CVDs; however, further research is needed to establish these findings in humans.
Previous studies have reported the potential benefits of targeting the gut microbiota through dietary or pharmacological interventions to manage the risk of CVDs. Moreover, these studies suggest that pre- and probiotics can protect against CVDs by restoring functional and structural changes in the gut microbiome to ultimately maintain immune homeostasis.
The administration of PTS has been shown to prevent obesity, as well as the weight gain and metabolic dysfunction that can arise when consuming a hypercaloric diet. PTS may also reduce inflammation, improve glucose and hepatic homeostasis, regulate lipid metabolism, and improve the thermogenic activity of brown adipose tissue.
Lactobacillus fermentum CECT5716 and Bifidobacterium breve CECT7263 also appear to reduce high blood pressure, which is a significant risk factor for both renal and CVDs. The anti-hypertensive effects of these strains may be attributed to their activation of Toll-like receptor 7 , which is associated with hypertension, endothelial dysfunction, and gut dysbiosis.
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