The genetics of resting heart rate and its connection to cardiovascular disorders NatureComms heartrate cardiovasculardisease cardiovascular heartrate restingheartrate
By Vijay Kumar MalesuAug 7 2023Reviewed by Sophia Coveney In a recent study published in Nature Communications, a group of researchers investigated the genetics behind resting heart rate and its impact on cardiovascular disease, correcting previous biases and providing novel insights into disease development.
Detailed genomic analysis was done, with each cohort subjected to rigorous quality control procedures. Genetic correlation analyses identified significant links with previous traits. Definitions of health conditions and longevity were collected, and exceptions were applied in certain cases. Blood pressure values were obtained and corrected for medication use. Detailed statistical analysis was carried out for functional outcomes, external cohort definitions, and genome-wide association studies. Replication analysis, quality control, regression analyses, and additional exclusions were done to enhance reliability.
Study results In the present study, the IC-RHR conducted a meta-analysis of RHR using 99 cohorts with 351,158 individuals and a GWAS on 484,307 UK Biobank subjects. This resulted in the analysis of 30,458,884 genotyped and imputed autosomal variants in 835,464 individuals, identifying 493 independent genetic variants.
The ECGenetics browser was used to explore the electrophysiological impact of RHR genetic variants, identifying 86 variants associated with a minimum of one ECG time point.
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