Similarities in gene expression between post-mortem and living human brains medrxivpreprint geneexpression gene expression postmortem human brains humanbrain brainhealth
By Dr. Priyom Bose, Ph.D.Aug 7 2023Reviewed by Benedette Cuffari, M.Sc. An important objective of medical research is to identify the underlying molecular mechanisms of human brain health and diseases.
*Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. Based on standardized neurosurgical procedures, PFC samples were obtained from living individuals who were subjected to deep brain stimulation . DBS is a widely used treatment for neurological and mental illnesses such as obsessive-compulsive disorder, Parkinson’s disease , and dystonia.
The expression of every gene associated with the trait of interest was analyzed using differential expression analysis. For a particular gene, the regression model beta captured both the magnitude and direction of the gene-trait association. Gene traits were collectively referred to as DE signatures of the trait.
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