The National Heart, Lung, and Blood Institute (NHLBI) recently awarded The Texas Heart Institute (THI) a two-year, $1.14 million grant to develop a novel, first-in-class drug to treat cardiovascular disease (CVD) as a significant improvement to current treatment regimens -; specifically for adverse events arising from atherosclerosis.
Reviewed by Megan Craig, M.Sc.Aug 22 2023 The National Heart, Lung, and Blood Institute recently awarded The Texas Heart Institute® a two-year, $1.14 million grant to develop a novel, first-in-class drug to treat cardiovascular disease as a significant improvement to current treatment regimens -; specifically for adverse events arising from atherosclerosis.
Conventional therapeutic approaches include the use of lipid-lowering statin drugs; however, many patients taking these medications still suffer life-threatening incidents often caused by residual inflammation risks. Indeed, many prominent clinical trials have established that atherosclerosis is an inflammatory disease and that lowering inflammation can reduce adverse cardiac events independent of statin drugs.
Dr. Darren G. Woodside, Vice President for Research, Senior Investigator, and Director of the Flow Cytometry and Imaging Core at The Texas Heart Institute Related StoriesDrs. Woodside and Biediger initiated a drug discovery and development program to target the molecular interactions between of a group of cell surface proteins called integrins and an intracellular protein termed Syk, which is important for producing IL-1β. Dr. Woodside's team recently published a study in Frontiers in Immunology indicating that such an interaction between integrins and Syk can be inhibited by small molecule compounds.
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