This recent study identifies new urinary biomarkers for detecting acute COVID-19 using spectroscopic analysis. The findings reveal that these biomarkers could offer valuable tools for early diagnosis, understanding the severity of the disease, and possibly contribute to endogenous immunological defense mechanisms against SARS-CoV-2.
By Pooja Toshniwal PahariaAug 29 2023 In a recent study posted to the medRxiv preprint* server, an international team of researchers evaluated metabolic responses to acute coronavirus disease 2019 and identified biomarkers for acute viral infections.
Background The COVID-19 pandemic has caused unprecedented morbidity and mortality globally. Effective therapeutics and tools for early detection and prompt treatment must be developed to mitigate disease. Research is required to improve our understanding of the biological characteristics of the causative virus, severe acute respiratory syndrome coronavirus 2 .
About the study In the present study, researchers elucidated candidate COVID-19 biomarkers by performing a spectroscopic analysis. To assess COVID-19 severity and its impact on the excretion of ddhN metabolites, the group of COVID-19 patients was subdivided into non-hospitalized and hospitalized individuals. The team investigated the excretion profiles of nucleosides in the initial week of SARS-CoV-2 infection among six COVID-19 patients who were diagnosed using polymerase chain reaction or rapid antigen tests . Flow cytometry was performed to quantify serological cytokines.
The analysis also revealed a correlation between the urinary analogs and viperin enzyme-related serological cytokines. The detection of ddhNs in serum was associated with inflammation, with the mean concentration of the three most abundant nucleosides being a minimum of one order of magnitude greater among individuals infected with SARS-CoV-2 compared to controls.
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