Study suggests threshold for type 2 diabetes diagnosis in women under 50 years should be lowered

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Study suggests threshold for type 2 diabetes diagnosis in women under 50 years should be lowered
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New research presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2–6 October) and published in the journal Diabetes Therapy suggests that the diagnosis threshold for type 2 diabetes (T2D) should be lowered in women aged under 50 years, since natural blood loss through menstruation could be affecting their blood sugar management. The study is by Dr. Adrian Heald, Salford Royal Hospital, UK, and colleagues.

of younger age with type 2 diabetes mellitus seem to have a higher mortality rate than men. The underlying mechanisms remain unclear. However, it is known that women are on average diagnosed with T2D at a later age than men.

The authors examined HbA1c testing across seven UK laboratory sites . They conducted an exploratory analysis in two cohorts: cohort 1 was from one laboratory tested between 2012 and 2019 . At age 50 years, average HbA1c levels in women lag by approximately five years compared to men. The data also show women aged under 50 years old had an HbA1c distribution that was lower than that of men by an average of 1.6 mmol/mol while the difference in the distribution of HbA1c for individuals aged 50 years and over was less pronounced.

This analysis showed that an additional 35,345 currently undiagnosed women in England would be reclassified as being diagnosed with T2D . Lifestyle changes and treatment for diabetes would then be initiated for these women enabling improvement in health outcomes over both the short and longer term.

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