Using a new recipe for growing blood vessels from living lung tissue in the lab, a University of Virginia School of Engineering and Applied Science research team has developed an analytical tool that could lead to a cure for idiopathic pulmonary fibrosis, or IPF, a lung-destroying disease.
Fibrosis is chronic scarring of tissue and it can strike nearly every system in the body. According to the National Institutes of Health, the government estimates that 45% of deaths in the United States can be attributed to fibrotic disorders. In the lungs, fibrosis restricts breathing, so understanding how scarring occurs, and ultimately how to stop it, are essential questions—especially in the case of IPF, a form of pulmonary fibrosis with no known cause.
Their work combines computational models of how blood vessels behave in the fibrotic lung developed by Leonard-Duke in Peirce-Cottler's lab with experiments using hydrogels engineered in Taite's lab. The result is a new investigative platform for studying the formation of blood vessels—a process called angiogenesis.
The research was published in Microcirculation, whose editors selected a figure from the paper to feature on the cover of the August 2023 issue.planted on a hydrogel, a water-swollen biomaterial that resembles a soft contact lens. Taite's lab functionalizes these hydrogels with bioactive molecules that closely mimic the angiogenic signals that encourage blood vessel development.
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