Study finds that pediatric stroke is associated with COVID-19 infections but not with multisystem inflammatory syndrome elsevierconnect UofUMedicine PediatricStroke MISC COVID19 Stroke SARSCoV2
By Dr. Chinta SidharthanNov 24 2022Reviewed by Aimee Molineux In a recent study published in Pediatric Neurology, researchers investigated whether coronavirus disease 2019 and multisystem inflammatory syndrome in children were associated with an increased risk of ischemic stroke in pediatric populations.
However, there is a scarcity of information on whether children with COVID-19 are at a higher risk of stroke. While studies have found no increase in the risk of ischemic stroke in pediatric COVID-19 patients during the early pandemic, neurological complications, and some forms of vasculopathy have been observed in a quarter of the MIS-C patients. Furthermore, while thromboembolism and stroke have been considered rare complications of MIS-C, the causal relationships are not well understood.
Results The results reported 16 cases of pediatric ischemic strokes in patients between the ages of eight months and 17 years. The incidence of ischemic stroke was correlated with an increase in COVID-19 infections in children but was not associated with an increased occurrence of MIS-C. Furthermore, acute SARS-CoV-2 infections were not found to be associated with stroke, suggesting that stroke could be associated with the hyperinflammatory state observed in COVID-19 patients in the two to six weeks after recovery. Additionally, the prothrombotic state and hypercoagulability that results from the activation of clotting cascades and endothelial damage due to the viral infection have also been implicated in the occurrence of strokes in pediatric patients.
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