Researchers evaluated the efficacy of semaglutide in patients with the obesity phenotype of heart failure and preserved ejection fraction.
By Tarun Sai LomteAug 31 2023Reviewed by Sophia Coveney In a recent study published in Nature Medicine, researchers evaluated the efficacy of semaglutide in patients with the obesity phenotype of heart failure and preserved ejection fraction .
Nevertheless, whether its effects differ by obesity class remains unclear. Studies report worsening symptom severity, hemodynamic abnormalities, and exercise limitations with increasing body mass index , suggesting the possibility that semaglutide’s effects may be limited to HFpEF subjects with high BMI.
Eligible subjects were randomized to semaglutide or placebo arms; they were instructed to perform frequent moderate-intensity physical activity and limit the intake of red meat, salt, sweets, sugar-sweetened beverages, trans or saturated fats, and alcohol. Patients were stratified according to BMI as class I , class II , or class III .
Related StoriesThe researchers did not observe differences in heart failure treatment and systolic blood pressure by obesity class. However, patients with a higher obesity class were more likely to be treated with higher doses of loop diuretics, and those with a lower obesity class were more likely to receive sodium-glucose co-transporter 2 inhibitors.
In the semaglutide group, weight loss was ≥ 20% in 58 patients, 15% to < 20% in 50 subjects, 10% to < 15% in 54 individuals, 5% to < 10% in 51 participants, and < 5% in 33 patients. The degree of weight loss was associated with the magnitude of CRP reduction and improvements in 6MWD and KCCQ-CSS.
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