Researchers at the University of Montana and their partners are nearing human trials for vaccines to prevent fentanyl and heroin drug overdoses.
. Once we establish safety and early efficacy in these first clinical trials, we hope to advance a combined multivalent vaccine targeting both heroin and fentanyl."
"Our vaccines are designed to neutralize the target opioid, while sparing critical medications such as methadone, buprenorphine, naltrexone and naloxone, which are used in treatment of opioid addiction and reversal of overdose," he said. A few years ago, UM earned a contract to develop and advance two candidate anti-opioid vaccines through Phase 1 clinical trials.
The Phase 1 human trials will be conducted with Dr. Comer at Columbia University in New York City. Evans said it could take six months or longer to recruit and enroll the required subjects: people who are using fentanyl or heroin. According to DrugAbuse.com, the relapse rate for heroin and opioid users hovers around 90%. Evans said the vaccines could save lives and help people seeking treatment."We start with the lowest dose—a dose that may not be effective," Evans said.
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