In a recent study, researchers evaluated the effects of chronic second-hand smoke exposure on cognition, behavior, neuropathology, and metabolism.
By Pooja Toshniwal PahariaAug 29 2023Reviewed by Sophia Coveney In a recent study published in Genes, researchers evaluated the effects of chronic second-hand smoke exposure on cognition, behavior, neuropathology, and metabolism.
About the study In the present study, researchers investigated whether SHS exposure induces gut microbial alterations, impacting cognitive performance, behavior, and neuropathology. Furthermore, the levels of the DNA repair marker AP endonuclease 1 were compared in SHS- and air-exposed mouse rats. Following SHS exposure, the levels of p21 and beta-galactosidase were also measured in mice.
Results The SHS exposure influenced the gut microbial composition, biodiversity, and evenness in a gender-dependent manner. This change in gut microbiome biodiversity and composition was similarly related to various cognitive function measures, demonstrating that the intestinal microbiota contributes to the impact of second-hand smoke exposure on cognitive abilities.
APE1 levels in the prefrontal cortex were greater in SHS-exposed murine mice than in air-exposed murine animals. Male mice exposed to SHS had considerably more alpha diversity in their microbiomes than female mice. Female mouse microbiome diversity was equivalent to that of air-exposed mouse microbiome diversity.
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