A new look inside Ebola's 'viral factories' ljiresearch NatureComms
. To interrogate both hypotheses, one can follow the changes in the appearance of network-like VFs in live cells infected with fluorescence-tagged Ebola virus using light microscopy in a high-containment laboratory.
Based on our confocal light and electron microscopy findings, we propose a model in which EBOV polymerase molecules act in concert in a spatially restricted manner. Having a group of EBOV polymerase molecules acting together on the same viral genome would compensate for the low efficiency of viral RNA synthesis, as a productive viral RNA synthesis event can only initiate at a single site at the 3′ end of the viral genome.
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Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage - Nature CommunicationsMacrophages are increasingly recognized as key drivers of lung damage in acute pneumonia including COVID-19. Here, the authors report on a first-in-class, inhalable, carbohydrate-coupled microRNA-inhibitor for selective targeting of macrophages and that prevents pulmonary hyperinflammation.
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Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer - Nature Biomedical EngineeringBone-matrix mineralization induces a less proliferative phenotype in breast cancer cells, as shown in collagen-based matrices with adjustable mineralization and in mice with xenografted bone matrices seeded with cancer cells.
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I tried “nature's Ozempic” Berberine - here's what happenedThe experts weigh in on Berberine 🙌
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Association between troponin level and medium-term mortality in 20 000 hospital patientsIntroduction Cardiac troponin (cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are frequently seen in hospital patients without a clinical presentation consistent with type 1 myocardial infarction, and the significance of this is uncertain. The aim of this study was to assess the relationship between medium-term mortality and cTn concentration in a large consecutive hospital population, regardless of whether there was a clinical indication for performing the test. Method This prospective observational study included 20 000 consecutive in-hospital and outpatient patients who had a blood test for any reason at a large teaching hospital, and in whom a hs-cTnI assay was measured, regardless of the original clinical indication. Mortality was obtained via NHS Digital. Results A total of 20 000 patients were included in the analysis and 18 282 of these (91.4%) did not have a clinical indication for cardiac troponin I (cTnI) testing. Overall, 2825 (14.1%) patients died at a median of 809 days. The mortality was significantly higher if the cTnI concentration was above the ULN (45.3% vs 12.3% p|0.001 log rank). Multivariable Cox analysis demonstrated that the log10 cTnI concentration was independently associated with mortality (HR 1.76 (95% CI 1.65 to 1.88)). Landmark analysis, excluding deaths within 30 days, showed the relationship between cTnI concentration and mortality persisted. Conclusion In a large, unselected hospital population, in 91.4% of whom there was no clinical indication for testing, cTnI concentration was independently associated with medium-term cardiovascular and non-cardiovascular mortality in the statistical model tested. No data are available. The nature of the data sharing agreement with NHS Digital prevents sharing of these data.
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Zoom promises not to feed vidchats into AI without permissioZoom updates its legalese with explicit statement it won’t automatically feed vidchats to AIs
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'Savage friend' goes viral for calling mate's date 'human skid mark'There's tough love, and then there's calling your mate's date a 'human skid mark' tough love 😂
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