Be warned.
The participants, both male and female, were divided into three groups. One, the placebo group, were not given any worms. A second group was inoculated with 20 worm larvae, and the third with 40 larvae.
The initial aim of the trial was to determine the safety of hookworm treatment, and while 44% of hookworm-treated participants experienced gastrointestinal symptoms, the drop out rate was roughly the same across all groups. Overall, the treatment was deemed safe. In addition, after two years, those treated with hookworms were found to have lower insulin resistance compared to an increase in the placebo group. Those treated with hookworms also lost more body mass, on average around 5kg.
Interestingly, a higher worm load did not result in better results, with those who received 20 hookworms showing a bigger decrease in insulin resistance than those who received 40.How the worms worked their magic however is still yet to be discovered, but the James Cook team is planning further, large-scale studies to better understand the mechanism.So effective in fact, all but one of the study participants chose to keep their hookworms at the end of the trial.
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