SARS-CoV-2 spike protein's role in lung injury unraveled: promising new approach uncovered SciReports spikeprotein COVID19 SARSCoV2 covid lunginjury
By Pooja Toshniwal PahariaJul 19 2023Reviewed by Lily Ramsey, LLM In a recent study published in Scientific Reports, researchers investigated the effect of severe acute respiratory syndrome coronavirus 2 spike protein subunit 1 on the pulmonary endothelium.
About the study In the present in vivo study, researchers assessed SARS-CoV-2 S1-induced endothelial cell damage in COVID-19 pathogenesis. They also investigated the potential activities of the C3a/C3a receptor axis in SARS-CoV-2 S1-induced damage to pulmonary tissue by examining the levels of certain C3aR at various time points across several pulmonary compartments.
Results In mice transgenic for human ACE2, S1 injection induced early loss of lung endothelial thromboresistance at three days, resulting in thrombomodulin loss and increased vWF levels. SB290157 treatment significantly reduced SARS-CoV-2 S1-induced endothelial C3 deposition at seven days, with CD46 restoration. C3aRa treatment also restored TM expression and reduced von Willebrand factor staining in the vascular wall within seven days.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Unraveling the consequences: COVID-19's devastating effect on the TB care cascadeUnraveling the consequences: COVID-19's devastating effect on the TB care cascade medrxivpreprint StellenboschUni covid COVID19 SARSCoV2 TB tuberculosis healthequity LMICs
Læs mere »
The infection connection: investigating the impact on dementia risk, neuroimaging revealsThe infection connection: investigating the impact on dementia risk, neuroimaging reveals medrxivpreprint ucl dementia neuroimaging infection dementiarisk
Læs mere »
Are antidrug antibodies reducing the effectiveness of rheumatoid arthritis treatment?Are antidrug antibodies affecting rheumatoid arthritis treatment ? JAMANetworkOpen arthritis antidrug antibodies treatment rhuematoid
Læs mere »
Impact of the 2022 European heat wave: Over 60,000 deaths recordedImpact of the 2022 European heat wave: Over 60,000 deaths recorded ISGLOBALorg UPFBarcelona umontpellier psl_univ heat heatwave climate weather
Læs mere »
Touching lives: understanding factors for successful touch interventionsTouching lives: understanding factors for successful touch interventions medrxivpreprint touchintervention touch mentalhealth physicalhealth research
Læs mere »
Meta-analysis confirms 17 key metabolites as strong predictors of goutMeta-analysis confirms 17 key metabolites as strong predictors of gout Nutrients_MDPI gout metabolites metaanalysis preditors prevention research
Læs mere »