Are antidrug antibodies affecting rheumatoid arthritis treatment ? JAMANetworkOpen arthritis antidrug antibodies treatment rhuematoid
By Dr. Chinta SidharthanJul 17 2023Reviewed by Sophia Coveney In a recent study published in JAMA Network Open, researchers examined the association between antidrug antibodies, such as those against the monoclonal antibodies targeting tumor necrosis factor and interleukin-6 receptor, and the response to treatments for rheumatoid arthritis such as biologic disease-modifying antirheumatic drugs .
A European study investigated the development of antibodies against biological drugs across cohorts of patients with multiple sclerosis, Crohn's disease, rheumatoid arthritis, and ulcerative colitis. It reported that using antibiotics and immunosuppressants lowered the risk of antidrug antibody development.
Related StoriesParticipants were eligible for the study if they were above the age of 18, were diagnosed with rheumatoid arthritis, and their physician had decided to initiate treatment with rituximab , tocilizumab , and TNF inhibitors such as infliximab, etanercept, and adalimumab. Routine biological tests were conducted, such as erythrocyte sedimentation rate, alanine aminotransferase, creatinine levels, aspartate aminotransferase, and blood cell counts. Data on medical history, body mass index , history of autoimmunity in the family, concomitant treatments, and tobacco use and exposure were also obtained.
The European League Against Rheumatism response after one year of therapy for rheumatoid arthritis was the primary objective. In contrast, the EULAR response at six months and at different time points between six months and 18 months, along with drug levels during each protocol visit were the secondary objectives of the study.
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