Optical-resolution photoacoustic microscopy is an up-and-coming biomedical imaging technique for studying a broad range of diseases, such as cancer, diabetes and stroke. But its insufficient sensitivity has been a longstanding obstacle for its wider application.
limit, enabling new biomedical applications and clinical translation in the future. The findings were published in the journalPhotoacoustic microscopy is a biomedical imaging technique that combines ultrasound detection and-induced photoacoustic signals to create detailed images of biological tissue. When biological tissue is irradiated with a pulsed laser, it generates ultrasonic waves, which are then detected and converted into electric signals for imaging.
For instance, in an ophthalmic examination, a low-power laser is preferred for more safety and comfort. Long-term monitoring of pharmacokinetics or blood flow requires low-dose imaging to alleviate perturbation to tissue functions, he added. They achieved the breakthrough by combining improvement in the photoacoustic sensor design and innovation of a 4D spectral-spatial filter algorithm for computation. They improved the sensor design by using a lab-customized high-numerical-aperture acoustic lens, optimizing the optical and acoustic beam combiner, and improving the optical and acoustic alignment. The SLD-PAM also utilizes a low-cost multi-wavelength pulsed laser, providing 11 wavelengths, ranging from green to red light.
First, SLD-PAM enabled high-quality in vivo anatomical and functional imaging. The super-low laser power and high sensitivity significantly reduced perturbations in eye and brain imaging, paving an avenue for clinical translation. Second, without compromising, SLD-PAM reduced photobleaching by about 85%, using lower laser power, and enabled the use of a much broader range of molecular and nanoprobes.
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