People living with HIV respond well to COVID-19 infection and vaccination FrontImmunol HIV COVID19 covid SARSCoV2 vaccination infection
By Dr. Liji Thomas, MDAug 7 2023Reviewed by Benedette Cuffari, M.Sc. A recent study published in Frontiers in Immunology examines the antibody response to natural infection or coronavirus disease 2019 vaccination in individuals living with human immunodeficiency virus infection.
Earlier research has shown reduced binding and neutralizing antibody responses following SARS-CoV-2 infection in PLWH with HIV in their bloodstream. In fact, severe COVID-19 induces higher antibody responses in PLWH, similar to that observed in people without HIV . However, this response is lower among those with mild disease not requiring hospitalization.
Related StoriesThe current study explores Fc-effector functions in unvaccinated PLWH and PWOH who were hospitalized due to COVID-19. Infections within this cohort were caused by SARS-CoV-2 D614G or Beta variants. The comparison group comprised similarly infected hospitalized PLWH and PWOH who had received the adenovirus vector ChAdOx1 vaccine.
In the vaccinated cohort, PLWH exhibited slower binding IgG responses after the first dose; however, their antibody titers eventually rose after the second vaccine dose. Conversely, PLWH exhibited faster ADCC responses with a higher slope over time, thus leading to an increased level by day 28 in PLWH after vaccination as compared to PWOH.
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