This study will test the responses of cells in lymph nodes before and after immunization with flu and COVID-19 vaccines and compare reactions in older and younger adults.
A pioneering study into human immunity is being launched today by Oxford Vaccine Group at the University of Oxford. The study, called LEGACY03, is being funded by the Medical Research Council part of UK Research and Innovation. By investigating how lymph nodes work, and how they make responses to vaccines in younger and older people, it has the potential to improve vaccine design for different age groups significantly.
As we age, our immune system changes and with it our response to vaccines. Our risk of complications from infections like flu and COVID-19 also increases and it is therefore important to understand these changes so that vaccinations can be better tailored for maximum efficacy to protect the most vulnerable.
Dr Katrina Pollock MRC Clinician Scientist in Vaccinology at the Oxford Vaccine Group, Department of Paediatrics Instead of just measuring the output of the vaccine, which is the antibodies in the blood, the LEGACY03 study will visualize the lymph nodes themselves using an ultrasound scanner and at the same time take a small number of cells from those lymph nodes to see how they are responding. Paired with information about what is happening in the blood, scientists can establish a detailed picture of how different vaccines work.
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