Researchers developed a novel clinical diagnostic screening test to identify pregnancies at risk of developing preeclampsia.
By Hugo Francisco de SouzaAug 31 2023Reviewed by Sophia Coveney In a recent study published in the journal Nature Medicine, researchers developed a novel clinical diagnostic screening test to identify pregnancies at risk of developing preeclampsia , a potentially life-threatening complication characterized by hypertension.
Identifying PE early in the gestation period is thus imperative for initiating clinical interventions to treat the condition during the critical period . About the study The present study aims to investigate if cfDNA methylation can be used to diagnose and assess PE risk in pregnant women during the critical initial 16 weeks of gestation, enabling potential clinical intervention. Researchers began by collecting cfDNA from conventionally diagnosed PE patients and gestation-matched controls .
Clinical parameters, including gestational age at sampling, fetal fraction, maternal age, body mass index , parity, method of conception, ethnicity, diabetes and smoking, were matched between case and control groups. Related StoriesResearchers then build a tenfold cross-validated model to predict a PE risk metric using cfDNAme data for 1,542 regions of interest obtained before or after 12 weeks of gestation.
The unsupervised model was found to cluster case and control cohorts separately using both cfDNA and placental- or blood cell-derived DNA.
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