Dementia is a group of brain diseases that share similar symptoms, such as memory, language, orientation, and behavioral issues. Vascular dementia generally develops in the elderly, affecting between 1% and 4% of people over the age of 65, according to Alzheimer's Switzerland. It is caused by vascular lesions that disrupt the blood supply to the brain, leading to the death of neurons.
, high cholesterol, diabetes and smoking. Preventive measures would become more effective with the discovery of new disease biomarkers that would enable a better identification of people at risk. And this is what the HUG and UNIGE team succeeded in by discovering the role of the CCR5 receptor in the development of vascular dementia., the study focused on CCR5, a receptor protein linked to chemokines, chemical messengers of the immune system.
This complex genetic association considerably increases the risk of vascular dementia."People over the age of 80 who carry this specific genotype are eleven times more likely to develop," explains Benjamin Tournier, Ph.D., a biologist in the Department of Psychiatry at the HUG, and a researcher in the Department of Psychiatry at the UNIGE Faculty of Medicine and first author of the study.
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New biomarker could help identify people at risk for vascular dementiaDementia is a group of brain diseases that share similar symptoms, such as memory, language, orientation, and behavioral issues. Vascular dementia generally develops in the elderly, affecting between 1% and 4% of people over the age of 65, according to Alzheimer's Switzerland.
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