The research paper reviews the potential benefits of marine plasmalogens, a type of glycerophospholipid, in combating age-related diseases like Alzheimer's and Parkinson's. These compounds, abundant in marine resources, could improve lipid metabolism and reduce oxidative stress, offering a new avenue for improving the quality of life in aging populations.
By Dr. Priyom Bose, Ph.D.Sep 3 2023Reviewed by Benedette Cuffari, M.Sc. Aging reduces metabolism and clearance, which leads to an increase in oxidative and inflammatory stress in the body. An individual’s quality of life, including diet and exercise, plays a crucial role in the prevention of age-related diseases.
What are plasmalogens? Marine resources contain essential nutrients not found in land resources, such as docosahexaenoic acid and eicosapentaenoic acid . Algae-derived xanthophylls are associated with both antioxidative activity and various food functions. Biological role of plasmalogens Plasmalogens strengthen lipid membranes and lower their fluidity, both of which are related to cellular functions. Moreover, plasmalogens scavenge reactive oxygen species at their alkenyl linkages.
Plasmalogens and age-related diseases The most common form of dementia is AD, and depending on the severity of the disease, the level of PlsEtn can be significantly reduced in the brain and serum of patients. A decline in the level of PlsEtn weakens the blood and brain, thus advancing AD symptoms. It has been hypothesized that blood plasmalogen levels are affected by oxidative stress and abnormal lipid metabolism. Therefore, it is essential to maintain cholesterol levels within the normal range for a healthy circulatory system.
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