Scientists from Queen Mary University of London have discovered two new genes that cause head and neck cancer patients to be resistant to chemotherapy, and that silencing either gene can make cancer cells previously unresponsive to chemotherapy subsequently respond to it.
The scientists first used a method known asto identify genes that may be affecting tumor responsiveness to drug therapy. They tested 28 genes on 12 strains of chemoresistant cancer cell lines, finding four 'significant' genes that were particularly responsive that they then investigated further and tested multi-drug resistance.
Dr. Muy-Teck Teh, senior author of the study from Queen Mary University of London, said,"These results are a promising step towards cancer patients in the future receiving personalized treatment based on their genes and tumor type that give them a better survival rate and treatment outcome. "Unfortunately, there are lots of people out there who do not respond to chemotherapy or radiation. But our study has shown that in head and neck cancers at least it is these two particular genes that could be behind this, which can then be targeted to fight against chemoresistance.
"Treatment that doesn't work is damaging both for the NHS and patients themselves. There can be costs associated with prolonged treatment and hospital stays, and it's naturally extremely difficult for people with cancer when their treatment doesn't have the results they are hoping for."
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