New study helps explain the anti-cancer properties of mannose sugar sbpdiscovery elife
. Your revised article has been evaluated by Richard White and a Reviewing Editor.
The stable isotope tracing experiments have problems that leave this point unaddressed. Specifically: 2. U-13C6-glucose is not suitable to assay the non-oxidative and oxidative branches of the PPP and thus the authors cannot conclude that mannose decreases flux into this pathway. The authors should use 1,2-C2-glucose tracing to draw these conclusions and also perform labeling with additional tracers to parse where the defects in nucleotide synthesis are occurring.
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