A new multilayered approach discovers 50 novel candidate genes for Parkinson'sdisease
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Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis - Genome BiologyBackground Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality. Dynamic control of DNA methylation is therefore vital for embryogenesis, yet the underlying mechanisms remain poorly understood. Results Here we report a single-cell transcriptomic atlas from Dnmt and Tet mutant mouse embryos during early organogenesis. We show that both the maintenance and de novo methyltransferase enzymes are dispensable for the formation of all major cell types at E8.5. However, DNA methyltransferases are required for silencing of prior or alternative cell fates such as pluripotency and extraembryonic programmes. Deletion of all three TET enzymes produces substantial lineage biases, in particular, a failure to generate primitive erythrocytes. Single-cell multi-omics profiling moreover reveals that this is linked to a failure to demethylate distal regulatory elements in Tet triple-knockout embryos. Conclusions This study provides a detailed analysis of the effects of perturbing DNA methylation on mouse organogenesis at a whole organism scale and affords new insights into the regulatory mechanisms of cell fate decisions.
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Higher body temperature alters key protein in autoinflammatory disorderA new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease.
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French study reports growing evidence of sexual activity-linked transmission of monkeypoxFrench study reports growing evidence of sexual activity-linked transmission of monkeypox Sorbonne_Univ_ TheLancet Monkeypox MonkeypoxVirus Transmission
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DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types - Nature CommunicationsHere the authors identify differences in cortical DNA methylation associated with Alzheimer’s disease pathology, and profiling nuclei from specific cell-types, find that most of these differences reflect variation occurring in non-neuronal cells.
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Rikki Neave police 'ignored scientific evidence'Original 1994 police inquiry ignored evidence and instead made murder case against boy’s mother, BBC finds.
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