Insights into the pathophysiological mechanisms governing neuropsychiatric symptoms of multiple sclerosis Nature MS multiplesclerosis neuropsychiatric symptoms research healthcare
By Neha MathurJul 21 2023Reviewed by Lily Ramsey, LLM In a recent study published in Translational Psychiatry, researchers pursued insights into the pathophysiological mechanisms governing neuropsychiatric symptoms of multiple sclerosis .
Emerging evidence of neuropsychiatric symptoms, including cognitive impairment, clinical depression, and anxiety in MS, has given valuable insights into the pathophysiology of the disease. Moving on to treatment approaches, both currently available or under investigation, they describe and evaluate pharmacological and rehabilitative approaches with beneficial effects on MS-related cognitive functioning, mood disorders, and fatigue.
The pathogenesis of MS-related depressive symptoms is multifactorial, with genetic and immunological players. Studies suggest that the Apolipoproteinε2 allele plays a protective role and decreases the incidence of depression. Anxiety disorders in MS patients vary with age, with an age-standardized prevalence of up to 35.6% reported in MS patients compared to 29.6% in the general population. Several brain regions, including the amygdala, hippocampus, and medial prefrontal cortex, have been implicated in MS-triggered modulation of anxiety disorders.
Being shorter, the Brief International Cognitive Assessment for multiple sclerosis and the Symbol Digit Modalities Test are more useful in clinical settings and provide critical data on executive functions, verbal fluency, and working memory. Here it is also noteworthy that children have a greater capacity to compensate for brain damage through neural plasticity. Thus, MS-triggered cognitive decline is more common in older than younger people.
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