Eternal youth? Chemical cocktails prove effective in cell age reversal harvardmed chemicalcocktail cocktail cellage cell cellbiology age aging agereversal reversal
By Pooja Toshniwal PahariaJul 19 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Aging Journal, researchers identified chemical drug combinations that could reverse cellular aging.
About the study In the present study, researchers devised high-throughput cellular assays that can differentiate between young, older, and aged cells of the body, including transcriptomic aging clocks and real-time quantitative nucleocytoplasmic compartmentalization assays, to identify compounds that can reverse the aging process without genomic alterations.
The fibroblasts were treated with doxycycline to activate the OSK system, and the NCC assay underwent testing to determine whether the system could identify the impact of genomically-regulated epigenetic age reversing. The study assessed the genetic expression patterns of chemically treated cells compared to aged human-origin cells and OSK-induced murine and human iPSC.
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