Gut microbial flavonoid catabolite reverses fatty liver disease in mice FattyLiver Hepatic Steatosis Liver LiverDisease flavonoid catabolite PNASNews ClevelandClinic
By Tarun Sai LomteNov 29 2022Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the Proceedings of the National Academy of Sciences , researchers report that a gut microbial catabolite could reduce the cardiometabolic disease burden in mice.
Study findings In the present study, the metabolic benefits of flavonoid consumption were found to be contingent on gut microbial metabolism. To come to this conclusion, the researchers initially tested the hypothesis that microbial catabolites of dietary flavonoids are responsible for anti-obesogenic properties.
Since 4-HPAA was previously reported to negatively correlate with obesity indices in non-diabetic obese humans, the researchers selected the catabolite for further investigations into whether it could abrogate HFD-induced metabolic disease. Ontology enrichment analysis elucidated the potential interactions of molecular pathways, including the positive regulation of fatty acid metabolic processes and the negative regulation of tumor necrosis factor production.
AMPKα and ACC were phosphorylated in primary mouse hepatocytes treated with 4-HPAA in vitro in a dose-dependent manner. Clinical studies suggest flavonoid catabolism is less prominent among human gut microbiota with a significant inter-individual variation.
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