Scientists at the University of Colorado Anschutz Medical Campus have made a 'paradigm shifting' discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer's disease and potentially Down syndrome. The study was published in the journal Nature.
Scientists at the University of Colorado Anschutz Medical Campus have made a 'paradigm shifting' discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer's disease and potentially Down syndrome. The study was published in the journalFor over 30 years, researchers believed that LTP or long-term potentiation, which is crucial for learning and memory, required enzymatic actions by an enzyme known as CaMKII.
That's significant, Bayer said, because it opens the door to the therapeutic use of a new class of inhibitors that target only the enzymatic activity of CaMKII, but not the structural functions required for memory and learning. The researchers found one group of inhibitors that protected from the Abeta effects without impairing LTP, making it potentially useful in treating a number of brain diseases without debilitating side effects.
Bayer said if the inhibitors work in humans, they could provide additional benefit in conjunction with any current AD treatment strategies.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Scientists reverse Alzheimer's plaque formation in animal models by boosting activity of key ion channelLosing the activity of a key ion channel in the brain may contribute to the buildup of a devastating and toxic protein responsible for the clumps of plaque that accumulate in Alzheimer's disease, a team of neurobiologists in China has found.
Læs mere »
Suriname Oil Boom Back On Track As New Discoveries Excite InvestorsDespite earlier setbacks and an economic crisis, Suriname's oil development appears more promising with TotalEnergies resuming its billion-dollar project in Block 58 and APA Corporation reporting significant new discoveries.
Læs mere »
How diet and exercise may rewrite the Alzheimer's script at a molecular levelResearchers explore how lifestyle changes like diet and physical activity can influence microRNA expression in Alzheimer's patients, potentially offering new therapeutic avenues. The study fills a research gap in understanding how such lifestyle modifications could affect molecular mechanisms implicated in Alzheimer’s disease.
Læs mere »
Online test nails early Alzheimer's diagnosis with biomarker precisionResearchers have developed a novel digital cognitive testing platform, using the Oxford Cognitive Testing Portal, that correlates with serological biomarkers to accurately measure cognitive impairment in Alzheimer's patients. The study highlights the platform's effectiveness in capturing subtle signs of impairment, potentially revolutionizing early diagnosis and tracking of Alzheimer's disease.
Læs mere »
Inflammatory diets raise dementia and Alzheimer's riskThis research study links higher Dietary Inflammatory Index (DII) scores to an increased risk of developing dementia, specifically Alzheimer's disease. The findings suggest that anti-inflammatory diets may offer a preventive strategy for dementia, underlining the need for further research to validate these associations.
Læs mere »
A 'mini-brain' traces the link between concussion and Alzheimer's diseaseHow much time elapses between a blow to the head and the start of damage associated with Alzheimer's disease?
Læs mere »