This research study links higher Dietary Inflammatory Index (DII) scores to an increased risk of developing dementia, specifically Alzheimer's disease. The findings suggest that anti-inflammatory diets may offer a preventive strategy for dementia, underlining the need for further research to validate these associations.
By Pooja Toshniwal PahariaAug 28 2023 In a recent study posted to the medRxiv preprint* server, researchers in the United States investigated whether higher Dietary Inflammatory Index scores were related to an increased incidence of dementia due to Alzheimer's disease or any other cause.
*Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. The study outcome was new-onset AD or any other cause of dementia. The study exposure was the cumulative Dietary Inflammatory Index score, derived based on prior studies that linked individual diet-related factors to inflammatory biomarkers such as tumor necrosis factor-alpha , C-reactive protein , and interleukins -1β, 4, 6, and 10. The Dietary Inflammatory Index was calculated using the validated 131.0-component Harvard semi-quantitative food frequency questionnaire.
The team used the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria to diagnose any-cause dementia, whereas the National Institute of Neurological and Communicative Disorders and Stroke and the AD and Related Disorders Association criteria to diagnose AD dementia. Higher or pro-inflammatory Dietary Inflammatory Index scores were linked to increases in any-cause and AD dementia incidences, adjusting for participants' gender and age , and the associations remained unaltered after additional adjustments for clinical, lifestyle, and demographic variables .
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